Technologies Used >> Levulan® Kerastick® |
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The FDA approved Levulan Kerastick (aminolevulinic acid HCl) for Topical Solution, 20%, to be used in conjunction with photodynamic therapy for treatment of actinic keratoses (AKs)(pre-cancerous skin lesions) of the face or scalp. It is the first combined drug and device treatment designed for targeted treatment that can be limited just to the lesion site(s). AKs are rough, scaly, red or brown patches that begin on the surface of the skin. They are mostly found among light-complected individuals. It affects over 50% of elderly fair-skinned persons in hot, sunny climates. They can also be found more rarely in individuals in their teens and twenties. Untreated, AKs may become malignant. The Levulan Kerastick is a two-stage treatment process which involves the topical application of aminolevulinic acid by a doctor or nurse directly to the individual AK lesions, followed by photodynamic therapy. Photoactivation of treated AKs is accomplished with blue light irradiation utilizing a special light source designed to provide a uniform distribution of blue light to the affected face or scalp areas. Dr. Kovak also utilizes Levulan Kerastick in conjunction with photodynamic therapy for the treatment of moderate to severe acne. The Levulan Kerastick dosage form was designed to treat the lesions, thereby reducing possible skin irritation of unaffected, non-lesional skin. The most common adverse event associated with treatment was local discomfort (stinging/burning sensation) during light treatment. |
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